Detalhe da pesquisa
1.
A lncRNA from the FTO locus acts as a suppressor of the m6A writer complex and p53 tumor suppression signaling.
Mol Cell
; 83(15): 2692-2708.e7, 2023 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37478845
2.
DNA Damage Promotes TMPRSS2-ERG Oncoprotein Destruction and Prostate Cancer Suppression via Signaling Converged by GSK3ß and WEE1.
Mol Cell
; 79(6): 1008-1023.e4, 2020 09 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32871104
3.
EZH2 cooperates with gain-of-function p53 mutants to promote cancer growth and metastasis.
EMBO J
; 38(5)2019 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30723117
4.
Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation.
Mol Cell
; 59(6): 904-16, 2015 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26344096
5.
AKT-phosphorylated FOXO1 suppresses ERK activation and chemoresistance by disrupting IQGAP1-MAPK interaction.
EMBO J
; 36(8): 995-1010, 2017 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28279977
6.
FOXO1 binds to the TAU5 motif and inhibits constitutively active androgen receptor splice variants.
Prostate
; 73(10): 1017-27, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23389878
7.
Gain-of-function mutant p53 together with ERG proto-oncogene drive prostate cancer by beta-catenin activation and pyrimidine synthesis.
Nat Commun
; 14(1): 4671, 2023 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37537199
8.
SETDB1 Modulates Degradation of Phosphorylated RB and Anticancer Efficacy of CDK4/6 Inhibitors.
Cancer Res
; 83(6): 875-889, 2023 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36637424
9.
TRABID overexpression enables synthetic lethality to PARP inhibitor via prolonging 53BP1 retention at double-strand breaks.
Nat Commun
; 14(1): 1810, 2023 03 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37002234
10.
Androgens repress expression of the F-box protein Skp2 via p107 dependent and independent mechanisms in LNCaP prostate cancer cells.
Prostate
; 72(2): 225-32, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21630295
11.
3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O'PROTAC.
Chem Commun (Camb)
; 58(14): 2383-2386, 2022 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35080528
12.
Mutated SPOP E3 Ligase Promotes 17ßHSD4 Protein Degradation to Drive Androgenesis and Prostate Cancer Progression.
Cancer Res
; 81(13): 3593-3606, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33762355
13.
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG.
Adv Sci (Weinh)
; 8(20): e2102555, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34397171
14.
HDAC5 Loss Impairs RB Repression of Pro-Oncogenic Genes and Confers CDK4/6 Inhibitor Resistance in Cancer.
Cancer Res
; 81(6): 1486-1499, 2021 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33419772
15.
An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors.
Cell Rep
; 34(7): 108744, 2021 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33596421
16.
SPOP mutation induces DNA methylation via stabilizing GLP/G9a.
Nat Commun
; 12(1): 5716, 2021 09 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34588438
17.
FOXA1 overexpression suppresses interferon signaling and immune response in cancer.
J Clin Invest
; 131(14)2021 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34101624
18.
Protein B23/nucleophosmin/numatrin nuclear dynamics in relation to protein kinase CK2 and apoptotic activity in prostate cells.
Biochemistry
; 49(18): 3842-52, 2010 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20387789
19.
RUNX2 overexpression and PTEN haploinsufficiency cooperate to promote CXCR7 expression and cellular trafficking, AKT hyperactivation and prostate tumorigenesis.
Theranostics
; 9(12): 3459-3475, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31281490
20.
Overcoming EZH2 Inhibitor Resistance by Taxane in PTEN-Mutated Cancer.
Theranostics
; 9(17): 5020-5034, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31410199